Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. RNA J. Li, Z. SobalaRon T. Ghildiyal, M. These studies demonstrated that ss-siRNAs could direct target cleavage although ss-siRNA triggers could only induce weak target cleavage activity compared to the duplex siRNA counterparts.
Mechanism of small RNA duplex loading into Argonaute proteins.
Small RNA sorting: matchmaking for Argonautes
Pederson, T. Intronic microRNA precursors that bypass Drosha processing. By combining the power of advanced nucleic acid chemistry and structural information of Argonaute complexes, it would probably be possible to further improve ss-siRNA design in more directed ways. Argonaute2 is the catalytic engine of mammalian RNAi. Cell 19— More publications by Nature Publishing Group.